Studies on the Chemical Constituents of Tripterygium Wilfordii

VernacularTitle:雷公藤化学成分研究
Author: Maosong QIU ¹ ; Yahui JIN ; Yuting XU ; Bao YANG ; Jinping ZHU ; Zhongxiang ZHAO ; Jing JIN
Author Information

1. 广州中医药大学中药学院广州510006
Keywords: Tripterygium wilfordii; Alkaloids; Terpenoids; NMR
From: China Pharmacist 2017;20(11):1910-1914
CountryChina
Language:Chinese
Abstract: Objective:To study the chemical constituents in the roots of Tripterygium wilfordii. Methods: The compounds from Tripterygium wilfordii were isolated and purified by silica gel, Sephadex LH-20 and prep-HPLC chromatography, and their structures were elucidated based on the physiochemical properties and spectroscopic analysis. Results:Twelve compounds were isolated and iden-tified as wilforgine(1),wilforine(2),triptonoterpene methyl ether(3),glut-5-en-3β,28-diol(4),wilforol E(5),triptobenzene L (6),maytenoic acid(7),triptophenolide(8),celastrol(9),demethylzeylasteral(10),1-desacetyl wilforgine(11) and wilfortrine (12). Conclusion:The 1D and 2D NMR data of 1 and 2 are assigned for the first time,and the absolute configurations of 1 are con-firmed by X-ray single crystal diffraction.