Analysis of Intestinal Absorption Characteristics of Matrine and Glycyrrhizic Acid
- VernacularTitle:苦参碱和甘草酸的小肠吸收特性分析
- Author:
Tao YAN
1
;
Wei JIANG
;
Qinhui WANG
;
Wei MU
;
Lei SHI
Author Information
1. 第四军医大学唐都医院药剂科 西安710038
- Keywords:
Matrine;
Glycyrrhizic acid;
SPIP;
HPLC;
Intestinal absorption
- From:
China Pharmacist
2017;20(11):1906-1910
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the absorption characteristics of matrine and glycyrrhizic acid in different intestinal segment and at various mass concentration,and explore the absorption changes of the combination of the two drugs.Methods:In situ single pass intestinal perfusion (SPIP) model was used,and the concentration changes of matrine and glycyrrhizic acid were determined by HPLC, and Kaand Peffwere calculated. Results:Matrine was absorbed in the whole of small intestine, and best in jejunum, and compared with the duodenum and ileum,the absorption had significant difference (P<0.05).The absorption at different mass concentrations had significant difference(P<0.05). The absorption of glycyrrhizic acid in small intestine was poor without significant differences in different intestinal segments and at various doses (P>0.05). After the combination of the two drugs, the absorption of matrine and glycyrrhizic acid had significant difference when compared with that of separated use(P<0.05). Conclusion:The absorption of ma-trine is dose-dependent,and with the dose increase,the absorption increases. Glycyrrhizic acid absorption does not change with mass concentration,and the absorption may be passive transport. The combination of the two drugs can improve the in vivo absorption of ma-trine and increase the concentration of glycyrrhizic acid in intestine.
