Research method of psoriasis based on HaCaT cells
- Author:
Jia-Feng WANG
1
;
Jie LI
;
Jin-Qi LI
Author Information
1. School of Medicine
- Keywords:
psoriasis;
HaCaT cells;
research method;
pathogenesis;
pharmacology
- From:
Chinese Journal of Pharmacology and Toxicology
2018;32(4):302-303
- CountryChina
- Language:Chinese
-
Abstract:
Psoriasis is a chronic,refractory,inflammatory skin disease that occurs in young adults.The traditional animal model cannot simulate the skin characteristics of patients with psoriasis effectively, so it is difficult to be used for in-depth study of psoriasis mechanism. Immortalized human epidermal cells (HaCaT)is a non-tumor,immortalized human epidermal cell which is widely used in the study of dermatosis.HaCaT cells are the best choice for the study of psoriasis mechanism because their immu-nological characteristics and reproductive ability are coincide with the pathological features of psoriasis. This article reviews the specific methods such as establishment of cell method, cytokine and chemo-kine analysisin the pathogenesis study of psoriasis based on HaCaT cells, hoping to provide some thoughts for drug′s pharmacological activity research.
