Relationship between PI3K/Akt signal and its downstream pathway and cardiovascular disease
- Author:
Yu-Hui SUN
1
;
Jing-Kun LU
;
Xing-Feng YAO
Author Information
1. College of Pharmacy
- Keywords:
PI3K/Akt;
FoxO3a;
coronary heart disease;
myocardial ischemia
- From:
Chinese Journal of Pharmacology and Toxicology
2018;32(4):300-300
- CountryChina
- Language:Chinese
-
Abstract:
A growing number of studies show that drug and non-drug means can be activated phosphatidyl inositol-3-kinase serine/threonine kinase(PI3K/Akt signaling pathway)in the beginning of reperfusion, and make its downstream fork protein transcription factor O3a (FoxO3a) phosphorylation, and then promote cell survival and reduce the apoptosis so as to alleviate the symptoms of myocardial ischemia.In this paper,the role of PI3K/Akt and FoxO3a effector in myocardial ischemia was reviewed, and illustrated the role of PI3K/Akt/FoxO3a signaling pathway in myocardial ischemia.
