An updated role of astragalosideⅣin heart failure
- Author:
Yi-Bei ZANG
1
;
Zhen QIN
;
Xia LIU
;
Wei-Dong ZHANG
Author Information
1. Shanghai University of Traditional Chinese Medicine
- Keywords:
heart failure;
astragaloside IV;
pharmacological effect
- From:
Chinese Journal of Pharmacology and Toxicology
2018;32(4):271-272
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure has become a global public health problem that seriously threatens human health. Due to "multi-target" effect, traditional Chinese medicine has unique advantages in the treat-ment of heart failure. Astragaloside Ⅳ is one of the main active ingredients of astragalus membrana-ceus.It has the functions of protecting the heart and neovascularization,anti-inflammation,anti-oxida-tion, regulating energy metabolism, neuroprotection and anti-cancer effects. This article reviews the recent progresses of astragaloside Ⅳ in the treatment of heart failure.Data show that astragaloside Ⅳcan inhibit heart fibrosis,attenuate excessively activation of renin-angiotensin system,increase energy metabolism, promote positive inotropic action, inhibit myocardial cell apoptosis, etc, which are all involved in the protective role of astragaloside Ⅳ in rodents or cellular models of heart failure.Astragalo-side Ⅳ may be a potential active ingredient in traditional Chinese medicine for the treatment of heart failure.
