Progress in potential targets for fast-onset antidepressants
10.3867/j.issn.1000-3002.2017.12.007
- VernacularTitle:快速起效抗抑郁药物的潜在靶标
- Author:
Ran ZHU
1
;
Li-Ming ZHANG
;
Yun-Feng LI
Author Information
1. 广西医科大学药学系
- Keywords:
antidepressant;
fast onset;
depression;
monoamine transmitters;
non-monoamine target
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(12):1194-1200
- CountryChina
- Language:Chinese
-
Abstract:
Depression has become a serious global public health concern and a prominent social problem.Moreover,the majority of first-line antidepressants that target monoamine neurotransmitter function have significant limitations (ie,low response rates,a time-lag of weeks for a response,cognitive impairment and sexual dysfunction),particularly with the delayed onset of clinical effects which will reduce the patients' clinical compliance and increase the patients' risk of suicide and self-harm.All this highlights a major unmet need for a new generation of antidepressants with fast onset action and low toxic side effects.There has been great progress in the study on pathogenesis of depression and drug targets so far.Recent research has shifted from increasing the level of monoamine neurotransmitter (NE/5-HT) to focusing on regulating the adaptive and plastic change of the nervous system,especially the discovery of new potential fast-onset non-monoaminergic targets including NMDA receptor,AMPA receptor and M choline receptor.This article reviews the investigation into generalized fast antidepressants and their potential targets,in the hope of providing critical information for the development of fastonset antidepressants.
