Role of P2X4 receptor,a subtype of ionotropic purinoceptors, in central nervous system and its potential role as a drug target for treating neurological disorders
10.3867/j.issn.1000-3002.2017.11.009
- VernacularTitle:离子通道型嘌呤受体P2X4在中枢神经系统中的作用及其作为神经系统疾病干预靶标的前景
- Author:
Xue-Fei MA
1
;
Ye YU
Author Information
1. 上海交通大学医学院药理与化学生物学系
- Keywords:
receptors;
purinergic P2X4;
central nervous system;
chronic pain;
antagonists
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(11):1091-1098
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine 5-triphosphate is not only the source of cellular energy,but also the extracel-lular signal molecule that binds two different classes of ATP receptors:ionotropic P2X receptors and G-protein-coupled P2Y receptors.P2X4 receptor is one of the ionotropic P2X receptors widely expressed in the central nervous system(CNS).This subtype of the ionotropic P2X receptor is implicated in many physiological and pathological functions in the CNS, including chronic pain, alcohol abuse, seizures, Alzheimer′s and Parkinson′s diseases,and stroke.Therefore,P2X4 receptor has attracted attention as a promising drug target.Here,we review the findings of research or the physiological and pathological functions of P2X4 in the CNS. Recent progress in the development of new pharmacological agents of P2X4,such as selective antagonists,is also presented here.
