Innate immune receptors mediated neuroinflammation in nervous system diseases
10.3867/j.issn.1000-3002.2017.11.007
- VernacularTitle:先天免疫受体介导的神经炎症在神经系统疾病中的作用
- Author:
Yuan DONG
1
;
Xiao-Heng LI
;
Lin HOU
;
Jin-Bo CHENG
Author Information
1. 青岛大学医学部
- Keywords:
innate immunity receptors;
neuroinflammation;
neurodegeneration diseases;
mental disorders;
brain injuries
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(11):1075-1083
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammation is closely associated with the development of neurodegeneration diseases, mental disorders and brain injuries. Innate immunity receptors are the first defense line against infections and injuries, which play a critical role in the neuroinflammation and nervous system diseases.This review,focuses on the type classification,function,regulatory mechanism for the innate immunity receptors,and illustrates their roles and molecular mechanism in the development of neuroin-flammation and nervous system diseases.In addition,we will review the current drugs for treating related nervous system diseases, and the possibility of developing new drugs that target neuroinflammation and using anti-inflammatory drugs clinically.
