Metabolic disorder of fatty acids and bile acids caused by organochlorine pesticides:research progress
10.3867/j.issn.1000-3002.2017.09.011
- VernacularTitle:有机氯杀虫剂致脂肪酸和胆汁酸代谢异常的研究进展
- Author:
Qian LIU
1
;
Wen-Tao SHAO
;
Ai-Hua GU
;
Zhao-Yan JIANG
Author Information
1. 南京医科大学公共卫生学院
- Keywords:
organochlorine pesticides;
fatty acids;
bile acids;
gut microbiota
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(9):934-938
- CountryChina
- Language:Chinese
-
Abstract:
Organochlorine pesticides(OCP)exist widely in the environment,which may threaten human health and cumulate for years once absorbed in the body.OCP metabolites in the body are associated with metabolic disorders.In vivo and in vitro exposure of OCP could enhance hepatic fatty acid synthesis, and interfere in the β-oxidation of fatty acids by impairing the function and structure of mitochondria in hepatocytes. Moreover, OCP can increase secondary bile acid formation by modulating of gut microbiota and reduceing ileal bile acid re-absorption,resulting in compensatory increase of hepatic bile acid synthesis. This review summarizes the mechanism of fatty acid and bile acid metabolic abnormalities caused by OCP.
