Progress on side effects of drugs induced by aortic binding
10.3867/j.issn.1000-3002.2017.09.010
- VernacularTitle:主动脉结合性质导致药物副作用的研究进展
- Author:
Zhao-Jin RAN
1
;
Bao-Shan CHAI
Author Information
1. 沈阳化工研究院有限公司医药研究室
- Keywords:
aortic binding;
cardiovascular diseases;
side effects
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(9):927-933
- CountryChina
- Language:Chinese
-
Abstract:
Some drugs, such as hydralazine, imidazole, muzolimine, rofecoxib, AZD5248 and ZD4407, have aortic binding character. The mechanism by which aortic binding impairs of elastin formation is analyzed here.Aortic binding research methods,such as[14C]labeled compound quantitative analysis,quantitative whole body autoradiography studies,in vitro benzaldehyde and propionic aldehyde reactivity assay and in vitro[14C]labeled compound competitive aortic tissue binding assay,are summa-rized.Studies show that aorta binding may induce side effects of drugs,which should become a health concern.
