Role of autophagy in doxorubicin-induced cardiotoxicity:review
10.3867/j.issn.1000-3002.2017.09.009
- VernacularTitle:自噬在多柔比星所致心脏毒性中的作用研究进展
- Author:
Sheng ZHANG
1
;
Lin YANG
;
Zhen-Qiang YOU
;
Yan-Fei XIN
Author Information
1. 浙江省医学科学院安全性评价研究中心
- Keywords:
doxorubicin;
cardiotoxicity;
autophagy
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(9):923-926
- CountryChina
- Language:Chinese
-
Abstract:
Doxorubicin (Dox) is an effective wide-spectrum antitumor drug. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanisms of cardiotoxicity have not been clearly elucidated, but are known to involve oxidative stress, mitochondrial dysfunction and apoptosis. Autophagy is a lysosome-dependent protein degradation pathway. More recently, many studies have suggested that autophagy plays an important role in Dox-induced cardiotoxicity. This paper gives a systematic review of the role of autophagy in Dox-induced cardiotoxicity.
