Epigallocatechin-3-gallate as an activator of Nrf2/ARE signaling pathway:a review

VernacularTitle:表没食子儿茶素没食子酸酯作为Nrf2/ARE信号通路激活剂的研究进展
Author: Fu YANG ¹ ; Xiu LIU ; Ming-Chun LI
Author Information

1. 青岛大学药学院药理学系
Keywords: epigallocatechin-3-gallate; Nrf2/ARE pathway; oxidative stress
From: Chinese Journal of Pharmacology and Toxicology 2017;31(8):832-839
CountryChina
Language:Chinese
Abstract: Epigallocatechin-3-gallate (EGCG) is not only the most active component of green tea, but the main object in green tea research. Numerous studies have shown that EGCG has cellular protec-tion functions, such as antioxidization, scavenging free radical , anti-cancer and antiapoptotic proper-ties. It has also been proved that EGCG could activate several signaling pathways. Nuclear factor erythroid-2p45 related factor 2/antioxidant response element (Nrf2/ARE) pathway is a key way to main-tain the redox homeostasis by regulating phase Ⅱ detoxification enzymes, and anti-inflammatory proteins. Recent studies have shown that EGCG plays an inportant role in the activation of Nrf2/ARE pathway in urinary, respiratory, cardiovascular, digestive systems. This review summarizes the research progress in EGCG as an activator of Nrf2/ARE signaling pathway, and provides reference for further research and exploitation of EGCG as potential medicine.