New Molecules in Babesia gibsoni and Their Application for Diagnosis, Vaccine Development, and Drug Discovery.
10.3347/kjp.2014.52.4.345
- Author:
Youn Kyoung GOO
1
;
Xuenan XUAN
Author Information
1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. gen@obihiro.ac.jp
- Publication Type:Review
- Keywords:
Babesia gibsoni;
serodiagnosis;
vaccine;
drug
- MeSH:
Animals;
Antigens, Protozoan/*diagnostic use/*immunology;
Antiprotozoal Agents/*isolation & purification/pharmacology;
Babesia/*drug effects/immunology/*isolation & purification;
Babesiosis/*diagnosis/drug therapy/prevention & control;
Dogs;
Drug Discovery/methods;
Protozoan Vaccines/*immunology
- From:The Korean Journal of Parasitology
2014;52(4):345-353
- CountryRepublic of Korea
- Language:English
-
Abstract:
Babesia gibsoni is an intraerythrocytic apicomplexan parasite that causes piroplasmosis in dogs. B. gibsoni infection is characterized clinically by fever, regenerative anemia, splenomegaly, and sometimes death. Since no vaccine is available, rapid and accurate diagnosis and prompt treatment of infected animals are required to control this disease. Over the past decade, several candidate molecules have been identified using biomolecular techniques in the authors' laboratory for the development of a serodiagnostic method, vaccine, and drug for B. gibsoni. This review article describes newly identified candidate molecules and their applications for diagnosis, vaccine production, and drug development of B. gibsoni.
