Study on neuroprotection of α-phenyl-N-tert-butyl nitrone for anti-Parkinson's disease in vitro and in vivo
10.3969/j.issn.1001-1978.2018.07.011
- VernacularTitle:α-苯基-N-叔丁基硝酮对MPP+/MPTP诱发帕金森病模型的神经保护作用
- Author:
Ting WEN
1
;
Yong-Li FU
;
Ting LUO
;
Kun ZHOU
;
Hong-Jie LI
Author Information
1. 华中科技大学同济医学院附属武汉精神卫生中心药学部
- Keywords:
PBN;
Parkinson's disease;
dopamine neurons;
oxidative stress;
free radicals;
neuroprotec-tion
- From:
Chinese Pharmacological Bulletin
2018;34(7):940-946
- CountryChina
- Language:Chinese
-
Abstract:
Aim To discuss the neuroprotection of an-tioxidant α-phenyl-N-tert-butyl nitrone ( PBN) in Par-kinson's disease ( PD) model. Methods The neuro-protective effects of PBN was explored on 1-methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahy-dropyridine ( MPP+/MPTP ) induced PD models through a chemical releasing of free radicals in neurons and in vivo. Results PBN significantly scavenged chemical derived free radicals, reduced MPP+induced SH-SY5Y injury and enhanced neurons' viability. In MPTP induced PD model, PBN significantly enhanced the number of tyrosine hydroxylase ( TH)-positive do-pamine ( DA) neurons in the substantia nigra, restored the expression of Nrf2 and HO-1, and raised striatal contents of DA and its metabolites. Conclusion PBN has a potent neuroprotective effect against MPP+/MPTP induced PD models.
