Molecular mechanism of alcohol-associated gastric cancer
10.3969/j.issn.1001-1978.2018.07.006
- VernacularTitle:酒精相关胃癌发生的分子机制
- Author:
Yi-Yin ZHANG
1
;
Hua WANG
;
Kang-Sheng GU
Author Information
1. 安徽医科大学第一附属医院肿瘤内科
- Keywords:
stomach neoplasms;
ethanol;
acetaldehyde;
carci-nogenesis;
molecular biology;
mechanism
- From:
Chinese Pharmacological Bulletin
2018;34(7):906-909
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is the second most common cancer in China. Alcohol consumption is related to gastric cancer as a sig-nificant risk factor. Some key enzymes is expected to influence the alcohol-associated metabolism. There are many molecular mechanisms of alcohol-related gastric cancer, such as generation of acetaldehyde by microbiome, inflammation, up-regulation of Pol Ⅲ genes, carcinogen-DNA adduct formation and genetic polymorphisms of alcohol metabolizing enzymes. Different types and concentrations of alcohol have different effects on the devel-opment of gastric cancer. This review presents a systematic ex-position on the molecular mechanism of alcohol-associated gastric cancer.
