Progress of prokineticin 2 in cardiovascular diseases
10.3969/j.issn.1001-1978.2018.07.002
- VernacularTitle:前动力蛋白2在心血管病变中的研究进展
- Author:
Cong HUANG
1
;
Min GUO
;
Juan CHEN
;
Fei CAI
;
You-Zhi ZHANG
Author Information
1. 湖北科技学院 药学院
- Keywords:
prokineticin 2;
prokineticin receptor 1;
prokineti-cin receptor 2;
myocardial infarction;
congestive heart failure;
vascular endothelial dysfunction
- From:
Chinese Pharmacological Bulletin
2018;34(7):892-894
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases are characterized by cardiac and vascular dysfunction. Prokineticin 2 ( PK2 ) is a newly found secretory peptide which plays a key role in the physiology homeostasis via prokineticin receptor 1 and 2 ( PKR1 and 2). Furthermore, PK2/PKR1 signaling pathway plays an important role in protecting cardiovascular diseases. Here we discuss the effect of PK2/PKR1 signaling in myocardial infarction, conges-tive heart failure and vascular endothelial dysfunction.
