Research progress on role of exosomes-shuttle-RNAs within central nervous system
10.3969/j.issn.1001-1978.2018.06.005
- VernacularTitle:外泌体源性RNAs在中枢神经系统中的研究进展
- Author:
Jin-Ying OU
1
;
Chan LI
;
Han-Cheng LI
;
Yu-Ting ZHOU
;
Chao-Hua LUO
;
Zhi-Xian MO
Author Information
1. 南方医科大学中医药学院中药药理学教研室
- Keywords:
exosomes;
RNAs;
miRNAs;
RNAs;
central nerv-ous system;
cell communication
- From:
Chinese Pharmacological Bulletin
2018;34(6):756-759
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are nanoscale vesicles produced and secre-ted into extracellular fluid by all cells. They mediate cell com-munication through carrying and transferring informational car-goes ( proteins, nucleic acids, lipids and so on ) to recipient cells. In central nervous system, exosomes can be released from all cell types including neurons, neural stem cells and neuroglia cells. These exosomes shuttle nucleic acids ( miRNAs, mRNAs and so on) and play an important role in nervous system devel-opment and function as well as diseases including Alzheimer's disease and drug addiction. Furthermore, the functional effects and targeting characteristics of exosomes-shuttle-RNAs suggest that exosomes-shuttle-RNAs can be diagnostic and therapeutic targets. In this review, we elaborate the effects, functions and mechanisms of exosomes-shuttle-RNAs in order to gain a new recognition of CNS development and diseases.
