Research progress in role and mechanism of ferroptosis in hepatocellular carcinoma
10.3969/j.issn.1001-1978.2018.06.002
- VernacularTitle:铁死亡在肝细胞癌中的作用以及研究进展
- Author:
Ling WANG
1
;
Yan JIA
;
Meng-Meng LI
;
Fei-Xia WANG
;
Zi-Li ZHANG
;
Feng ZHANG
;
Shi-Zhong ZHENG
Author Information
1. 南京中医药大学江苏省中药药效与安全性评价重点实验室
- Keywords:
ferroptosis;
hepatocellular carcinoma;
mechanism;
signal pathways;
iron;
lipid peroxidation
- From:
Chinese Pharmacological Bulletin
2018;34(6):745-749
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma ( HCC) is the most com-mon primary liver cancer resulted from various etiological fac-tors, among which HBV infection is the most important reason in China. The development and progression of HCC are regulated by a variety of cytokines and intracellular signaling pathways. In recent years, both clinical and basic studies have shown that fer-roptosis plays an important role in the occurrence of HCC. Fer-roptosis can affect the development of liver diseases by regulating the level of intracellular iron and lipid peroxidation. Many schol-ars believe that ferroptosis can be used as a target for the diagno-sis, prevention and treatment of HCC. In this review, the role of ferroptosis in HCC and its research progress has been summa-rized, including ferroptosis summary, the relationship between ferroptosis and HCC, and the molecular mechanisms of ferropto-sis in HCC.
