Anti-psoriatic effects of honokiol in imiquimod induced mouse model
10.3969/j.issn.1001-1978.2018.05.009
- VernacularTitle:和厚朴酚对咪喹莫特诱导小鼠银屑病的干预作用
- Author:
Qi-Bin ZHONG
1
;
Shu-Guang ZHU
;
Shao-Jun LU
;
Zhao-Xu CAI
;
Lin-Quan ZANG
Author Information
1. 广东药科大学药学院药理系
- Keywords:
honokiol;
imiquimod;
psoriasis;
IL-17;
IL-23;
JAK;
STAT3;
NF-κB;
TNF-α
- From:
Chinese Pharmacological Bulletin
2018;34(5):626-631
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the anti-psoriatic effects of honokiol on the mouse model induced by imiquimod and the underlying mechanism. Methods The mice were randomly divided into control group, model group, liposome solvent control group, dexamethasone positive group and honokiol high, medium, low dose groups. The progress of the disease was observed by the psoriasis area and severity index (PASI). The morphological changes of the skin cells were observed by HE staining, and epidermis thickness was meas-ured. The expression of IL-17, IL-23, JAK, STAT3, TNF-α and NF-κB was semi-quantitively analyzed by immunohistochemistry. Results Compared to model group, the scaling and thickness of honokiol treated groups were alleviated. Inflammatory infiltration and micro abscess were reduced. The expressions of IL-17, IL-23, JAK, STAT3, TNF-α and NF-κB in model group were higher than those in honokiol-high and honokiol-medium group in a dose-dependent manner. Conclusion Honokiol can inhibit imiquimod-induced psoriasis-like lesions in mice by inhibiting the IL-17/IL-23 inflammatory axis.
