Advances on epithelial mesenchymal transformation and airway remodeling of asthma
10.3969/j.issn.1001-1978.2018.05.003
- VernacularTitle:上皮间质转化与哮喘气道重塑的研究进展
- Author:
Pan WEI
1
;
Lian-Qu LI
;
Peng WU
;
Zhi-Rong JIA
;
Xiao-Yu WANG
;
Min HONG
;
Guo-Rong JIANG
Author Information
1. 南京中医药大学药学院
- Keywords:
airway remodeling;
epithelial-mesenchymal transi-tion;
asthma;
structural protein;
phenotypic transformation;
air-way inflammation
- From:
Chinese Pharmacological Bulletin
2018;34(5):600-603
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a respiratory system disease char-acterized by airway remodeling as a pathological basis. Repeated inflammatory infiltration and tissue damage repair can lead to airway remodeling. At present,the mechanism of airway remod-eling is not comprehensive. Studies have shown that epithelial-mesenchymal transition (EMT) plays an important role in the genesis and development of airway remodeling. Airway epithelial cells can be induced to mesenchymal transition through a variety of secretion factors and signaling pathways,leading to airway re-modeling in asthma. This review summarizes the study of EMT and airway remodeling in asthma,providing a reference for clini-cal follow-up treatment and research.
