L-type calcium channel involved in heterogeneity of arterial constriction in different organs of rats
10.3969/j.issn.1001-1978.2018.04.024
- VernacularTitle:L-型钙通道参与大鼠动脉收缩反应的异质性
- Author:
Lin LIU
1
;
Su-Juan KUANG
;
Hui YANG
;
Fang RAO
;
Meng-Zhen ZHANG
;
Li-Ping MAI
;
Qiu-Xiong LIN
;
Zhi-Xin SHAN
;
Min YANG
;
Chun-Yu DENG
Author Information
1. 南方医科大学药学院
- Keywords:
arterial heterogeneity;
L-type calcium channel;
vasoconstrictor;
vascular tension;
thoracic a-orta;
intrarenal artery;
coronary artery
- From:
Chinese Pharmacological Bulletin
2018;34(4):563-569
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study whether there was arterial heterogeneity and association with L-type calcium channel (LCC) in different parts of arteries in re-sponse to certain vasoconstrictor. Methods The aor-ta, renal arteries and coronary arteries were dissected from rats. Arterial ring contractions induced by pheny-lephrine (Phe), 5-hydroxyl tryptamine (5-HT) or U46619 in concentration-dependent manner were meas-ured using the Multi Myograph system and the response to nifedipne was observed. Results (1) Phe had no obvious effect on the tension of coronary artery,but in-duced concentration-dependent vasoconstriction in aor-ta and renal artery,and pEC50of aorta was significantly higher than that of renal artery (P<0.05). The inhi-bition rate of nifedipine on the aortic contractile re-sponses was significantly higher than that of renal arter-y (P<0.05). (2) The contraction induced by 5-HT on aorta was not obvious, but was significant on renal artery and coronary artery. The inhibitory rate of nife-dipine on coronary artery vasoconstriction was signifi-cantly higher than that of renal artery (P <0.05). (3) U46619 could induce aorta,renal artery and coro-nary artery concentration- dependent contraction, but the Emaxof them were both higher than that of renal ar-tery (P<0.05). And the pEC50of aorta was the lar-gest (P<0.05). Nifedipine significantly inhibited the contraction of aorta, renal artery and coronary artery induced by U46619 with the greatest inhibitory rate on the coronary artery vasoconstriction and minimal inhibi-tion on aortic vasoconstriction. Conclusions The re-sponse to certain vasoconstrictor is different among aor-ta, renal artery and coronary artery in rats, and the contraction mediated by L-type calcium channel is also different.
