The therapeutic effect of rh-aFGF carbomer 940 gel on wound healing in type I diabetic SD rat models
10.3969/j.issn.1001-1978.2018.04.023
- VernacularTitle:rh-aFGF卡波姆940凝胶对1型糖尿病大鼠皮肤创伤的修复作用
- Author:
Xuan-Xin YANG
1
;
Qi HUI
;
Gao-Zhong CAO
;
Jian-Guo LIU
;
Xiao-Xiao DU
;
Xiao-Kun LI
;
Xiao-Jie WANG
Author Information
1. 温州医科大学药学院
- Keywords:
recombinant acid fibroblast growth factor;
skin trauma;
Carbomer 940;
gel preparation;
skin wound;
healing rate
- From:
Chinese Pharmacological Bulletin
2018;34(4):557-562
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the therapeutic effect of re-combinant human acidic fibroblast growth factor (rh-aFGF) carbomer 940 gel in the treatment of skin wound healing in type I diabetic rats. Methods Two types of skin trauma models, namely, full-thickness wound and scalded wound,were established in a model of type I diabetes mellitus using STZ-induced SD rats. The rats were divided into control group, vehicle group,90 AU rh-aFGF gel group and 270 AU rh-aFGF gel group in each skin wound models. The wound area and wound healing rate were used to evaluate the thera-peutic effect. The growth of fibroblasts, fibrocytes, collagen fibers and vessel capillaries in the wound was observed using HE staining and analysed by semi-quantitative score. Results The rh-aFGF carbomer gel significantly reduced the traumatic area as well as promoted the wound healing rate of the skin trauma model of SD rats of type I diabetes mellitus (P <0.05). HE staining showed that rh-aFGF carbomer gel significantly promoted the pathological score of fibro-blasts and collagen fibers(P<0.05). Conclusions rh-aFGF carbomer gel might play a protective role in micro-environment of wound and rh-aFGF, which could benefit for proliferation of fibroblasts and colla-gen, therefore promoting the healing process of skin wound in SD rats with type I diabetes mellitus, and it might be expected to be a new preparation for the treat-ment of chronic trauma in diabetes mellitus.
