Regulation on intercross effect between Cdk5 mediated apoptosis and autophagy after cerebral ischemia
10.3969/j.issn.1001-1978.2018.04.006
- VernacularTitle:Cdk5介导的凋亡与自噬交互作用对脑缺血的调控
- Author:
Fang LIU
1
;
Xiao-Jiang ZHOU
;
Nai-Hong CHEN
Author Information
1. 湖南中医药大学药学院
- Keywords:
cerebral ischemia;
cyclin-dependent kinase 5;
PKB;
neuronal apoptosis;
autophagy;
intercross effect
- From:
Chinese Pharmacological Bulletin
2018;34(4):463-466
- CountryChina
- Language:Chinese
-
Abstract:
Cyclin-dependent kinase 5 (Cdk5),as a key neuro-nal regulator,has received extensively attention. In our previous experiments, we have preliminary confirmed the importance of the regulation on neuronal apoptosis after cerebral ischemia by Cdk5 signal path. According to the documents reported, we found that there were signal transductions between apoptosis and autophagy, which acted the"rapier"position after cerebral is-chemia. Furthermore,Cdk5 could mediate protein kinase B(Akt or PKB) to play bidirectional regulation on the intercross be-tween apoptosis and autophagy. So,there would be of great sig-nificance to reveal the signal transduction relationship between apoptosis and autophagy mediated by Cdk5. Owing to the impor-tance of the intercross-effect between the two programmed cell death paths,we aimed at the imparity viewpoints between apop-tosis and autophagy after cerebral ischemia, raising the sugges-tions as follows:it is appropriate to reveal the effects of Cdk5 on Akt kinase dynamically, and discuss the double regulation mechanism of co-regulators between apoptosis and autophagy af-ter cerebral ischemia, which would provide references for the following researches.
