Application and prospect of mitotherapy in mitochondria-related diseases
10.3969/j.issn.1001-1978.2018.04.005
- VernacularTitle:线粒体治疗在线粒体相关疾病治疗中的应用及展望
- Author:
Hua-Jing ZHANG
1
;
Meng-Nan ZHAO
;
Chen FU
;
Ai-Ling FU
Author Information
1. 西南大学药学院
- Keywords:
organelle transplantation;
mitotherapy;
mitochondrial disease;
mechanism;
mitochondria;
mi-tochondrial transfer
- From:
Chinese Pharmacological Bulletin
2018;34(4):459-463
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria is an important organelle in mammalian cells with multiple functions,such as ener-gy production and cell homeostasis maintaining. It is known that hundreds of diseases are associated with mi-tochondrial defects. The studies show that the exoge-nous mitochondria can directly enter mammalian cells in vitro, and they also can quickly transform into ani-mal tissues by local or intravenous injection. Current-ly, it has raised a new therapeutic strategy for mito-chondrial diseases, called mitotherapy, which trans-plants exogenous functional mitochondria into mito-chondria-defective cells. The mitochondria in recipient cells play their own roles, including energy produc-tion,maintaining free radical balance,and cell viabili-ty recovery. Since there is no effective method for mito-chondria-related diseases up to now, the mitotherapy will provide a new approach for the prevention and treatment of these diseases.
