Human immunodeficiency virus animal models and related neuropathy study
10.3969/j.issn.1001-1978.2018.04.001
- VernacularTitle:人类免疫缺陷病毒动物模型在相关神经病变的研究应用
- Author:
Zhi-Hua YI
1
;
Cong-Fa ZHOU
;
Xue-Ying HE
;
Shang-Dong LIANG
Author Information
1. 南昌大学护理学院
- Keywords:
human immunodeficiency virus;
HIV-1 animal model;
HIV associated neurocognitive disorders;
peripheral neu-ropathy;
neuropathic pain;
neuroinflammation
- From:
Chinese Pharmacological Bulletin
2018;34(4):445-449
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus(HIV) infection may result in serious impairment of the immune system in HIV-posi-tive patients. Both HIV productions and highly active antiretrovi-ral therapy (HAART) drugs can cause neuropathy, including the HIV associated neurocognitive disorders (HAND) and the peripheral neuropathy. Several animal models have been devel-oped in an attempt to study the mechanisms of HIV relative neu-ropathies. This review focuses on researching HIV-1 associated neuropathies by application of HIV-1 animal models.
