Advances in small molecular drugs targeted mutant p53
10.3969/j.issn.1001-1978.2018.03.006
- VernacularTitle:靶向突变p53的小分子药物研究进展
- Author:
Yu-Ling WANG
1
;
Yong-Nan SU
;
Ya-Feng BAO
;
Zhi-Kuan YANG
;
Han-Chuan MOU
;
Ji-Hong ZHANG
Author Information
1. 昆明理工大学医学院衰老与肿瘤分子遗传学实验室
- Keywords:
mutant p53;
target;
conformation;
drug design;
mechanism
- From:
Chinese Pharmacological Bulletin
2018;34(3):321-324
- CountryChina
- Language:Chinese
-
Abstract:
Tumor suppressor p53 protein can regulate the tran-scription of target genes, to control cell apoptosis, aging and other life activities,but mutant p53 is prone to losing antitumor function, thus promoting tumor development. At present, p53 protein has become one of the hot targets for the treatment of cancer. This article mainly introduces the structure and mechanism of small molecular compounds with restoring activity of mutant p53 as the target.
