A Childhood Case of Nephrotic Syndrome Complicated with Cerebral Venous Sinus Thrombosis Followed by Left Popliteal Artery Thrombosis.
- Author:
Si Eun LEE
1
;
Sue Jin LEE
;
Yang Suk JUNG
;
Jae Young LIM
;
Chan Hoo PARK
;
Hyang Ok WOO
;
Jin Jong YOO
;
Hee Shang YOUN
Author Information
1. Department of Pediatrics, Gyeongsang National University, College of Medicine, Chinju, Korea.
- Publication Type:Case Report
- Keywords:
Steroid responsive nephrotic syndrome;
Cerebral venous sinus;
Superior sagittal sinus;
Popliteal artery;
Thrombosis
- MeSH:
Angiography;
Antithrombin III;
Arteries;
Brain;
Cerebral Veins;
Child;
Dehydration;
Diagnosis;
Diarrhea;
Heparin;
Humans;
Hypovolemia;
Leg;
Male;
Nephrotic Syndrome*;
Plasma;
Popliteal Artery*;
Proteinuria;
Recurrence;
Reperfusion Injury;
Sinus Thrombosis, Intracranial*;
Superior Sagittal Sinus;
Thrombosis*;
Vomiting;
Warfarin
- From:Journal of the Korean Pediatric Society
1999;42(7):1019-1025
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a 10-year-old male with steroid-responsive nephrotic syndrome which was complicated by cerebral venous sinus thrombosis including superior sagittal sinus and left popliteal artery thrombosis following 5 months later. At each thrombotic episode, he suffered from relapse of massive proteinuria with hypovolemic crisis, and from hemoconcentration with dehydration due to vomiting or diarrhea. Brain MR angiography confirmed thromboses of superior sagittal sinus, straight sinus, vein of Galen and occipital sinus. Diagnosis of left popliteal artery thrombosis was made according to the clinical observations including pulseless left dorsalis pedis artery, pain and coldness of left lower leg, and reperfusion injury of calf muscle after heparinization. Each thrombotic episode was successfully managed with heparinization, oral warfarin therapy and fresh frozen plasma for the antithrombin III replacement.
