Mechanism of ferroptosis and its role in neurological diseases
10.3969/j.issn.1001-1978.2018.02.005
- VernacularTitle:铁死亡的机制及其在神经疾病中的作用
- Author:
Yi-Na JIANG
1
;
Song-Wei YANG
;
Xin ZHANG
;
Lin-Ming LUO
;
Zhao ZHANG
;
Nai-Hong CHEN
Author Information
1. 湖南中医药大学药学院
- Keywords:
ferroptosis;
neurodegenerative disease;
Alzheimer's disease;
Parkinson's disease;
Huntington's disease;
stroke;
periventricular leukomalacia
- From:
Chinese Pharmacological Bulletin
2018;34(2):166-170
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is distinct from apoptosis,autophagy,necrosis,cornification and other cell deaths from morphological,biochemical as well as genetic aspects.Ferroptosis plays a critical role in neurological diseases and cancers.Neurological diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,stroke,periventricular leukomalacia and so on,are characterized by multiple etiologies and mechanisms,and are potentially correlated with ferroptosis.Based on the recent researches on ferroptosis and neurological diseases,this review investigates ferroptosis and its role in neurological diseases.
