Analysis of Risk Factors of Hemorrhagic Transformation after Thrombolytic Therapy Using Recombinant Tissue Plasminogen Activator in Patients with Acute Ischemic Stroke
10.12007/j.issn.0258-4646.2017.12.010
- VernacularTitle:急性脑梗死患者重组组织型纤溶酶原激活剂静脉溶栓后出血性转化的危险因素分析
- Author:
Bingbo ZHOU
1
;
Xiaohong WANG
;
Jun YANG
Author Information
1. 中国医科大学附属第一医院神经内科
- Keywords:
ischemic stroke;
thrombolytic therapy;
hemorrhagic transformation;
risk factor
- From:
Journal of China Medical University
2017;46(12):1101-1104,1110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors associated with hemorrhagic transformation after administration of thrombolytic therapy using recombinant tissue plasminogen activator (rt-PA) in patients diagnosed with acute ischemic stroke.Methods The design for this research was a case-control study-21 patients with hemorrhagic transformation after administration of thrombolytic therapy using rt-PA were categorized as cases,and 63 patients without hemorrhagic transformation after administration of thrombolytic therapy using rt-PA were categorized as controls.Univariate and multivariate logistic regression analysis were performed to analyze the risk factors associated with hemorrhagic transformation after administration of thrombolytic therapy using rt-PA in patients diagnosed with acute ischemic stroke.Results Results of univariate analysis showed that positive baseline National Institutes of Health Stroke Scale (NIHSS) scores ＞ 10,hypertension,baseline systolic blood pressure (SBP) ≥ 140 mmHg,increased blood glucose level,history of atrial fibrillation,and cerebrovascular disease (CVD) were significantly higher in the case group than in the control group.Results of multivariate logistic regression analysis showed that baseline SBP ≥ 140 mmHg (OR =14.59,95％ CI:1.63-130.95),increased blood glucose level (OR =9.92,95％ CI:0.97-101.24),and history of CVD (OR =10.75,95％ CI:1.76-65.78) were independent risk factors associated with hemorrhagic transformation after administration of thrombolytic therapy using rt-PA in patients diagnosed with acute ischemic stroke.Conclusion Baseline SBP ≥ 140 mmHg,increased blood glucose level,and history of CVD were observed to be independent risk factors associated with hemorrhagic transformation after administration of thrombolytic therapy using rt-PA in patients diagnosed with acute ischemic stroke.
