Expression and Clinicopathological Significance of LAMP2a in Colorectal Cancer
10.12007/j.issn.0258-4646.2017.11.003
- VernacularTitle:结直肠癌中LAMP2a编码蛋白的表达及临床病理意义
- Author:
Shuai SHI
1
;
Jianhua DOU
;
Guangbo TANG
;
Shuang ZHAO
;
Yongzhan NIE
;
Huachuan ZHENG
Author Information
1. 锦州医科大学附属第一医院肿瘤基础与转化实验室
- Keywords:
colorectal cancer;
lysosome associated membrane protein-2a;
carcinogenesis;
progression;
prognosis
- From:
Journal of China Medical University
2017;46(11):970-975
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological and prognostic significance of lysosome-associated membrane protein-2a (LAMP2a) expression in the development of colorectal cancer.Methods Immunohistochemistry was performed to detect the LAMP2a expression in colorectal cancer,normal mucosa,and adenoma tissues.Results LAMP2a expression in colorectal cancer and adenoma was higher than that in normal mucosa (P ＜ 0.05).Further,LAMP2a expression in colorectal cancer was negatively correlated with TNM staging and lymph node metastasis (P ＜ 0.05);however,the invasion and liver metastasis,depth of invasion and differentiation had no correlation with the lymph node (P ＞ 0.05).Kaplan-Meier analysis showed that LAMP2a expression in colorectal cancer is not significantly correlated with good prognosis (P ＞ 0.05).Univariate survival analysis showed that lymphatic invasion,vascular invasion,lymph node metastasis,TNM stage,liver metastasis,distant metastasis,and differentiation were correlated with poor prognosis of colorectal cancer (P ＜ 0.05).The Cox proportional hazards regression model showed that the depth of invasion and distant metastasis were important factors affecting the survival period of patients with colorectal cancer (P ＜ 0.05).Conclusion LAMP2a may play a role in the carcinogenesis and progression of colorectal cancer,and may be used as a molecular marker for the biological behavior of colorectal cancer.
