Age-specific Reference Ranges for Prostate-specific Antigen in Dalian
10.12007/j.issn.0258-4646.2017.10.016
- VernacularTitle:大连地区男性年龄相关前列腺特异性抗原参考值范围
- Author:
Kai CAI
1
;
Zhiyu LIU
;
Liang WANG
;
Zhihong DAI
;
Jie SU
Author Information
1. 大连医科大学附属第二医院泌尿外科
- Keywords:
age;
prostate-specific antigen;
reference range
- From:
Journal of China Medical University
2017;46(10):927-930
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the age-specific normal ranges of serum prostate-specific antigen (PSA) levels in Dalian,China.Methods Serum samples were collected from 8 453 asymptomatic men who underwent health examinations at the Second Affiliated Hospital of Dalian Medical University.Results The median PSA level was 0.93 μg/L,and the interquartile level was 0.81 μg/L.The 95th percentile level was 3.49 μg/L.The 95th percentile levels according to age group were:20 to ＜30 years,0 to 1.67 μg/L;30 to ＜40 years,0 to 2.01 μg/L;40 to ＜50 years,0 to 2.41 μg/L;50 to ＜60 years,0 to 3.25 μg/L;60 to ＜70 years,0 to 3.92 μg/L;70 to ＜80 years,0 to 5.48 μg/L;and older than 80 years,0 to 9.35 μg/L.The differences between the different age groups were statistically significant (P ＜ 0.01).The serum PSA value was positively correlated with age (r =0.251,P ＜ 0.001).Conclusion There were clear differences in age-specific PSA levels in Dalian,and these were lower than the standard OESTERLING.Screening for prostate cancer according to age-specific PSA reference values may be useful in the early detection of prostate cancer and may also reduce the risk of over-diagnosis.
