Polymorphisms in GLIS3 Associated with Diabetic Retinopathy in Patients with Type 2 Diabetes in Northeast China

VernacularTitle:东北地区GLIS3基因多态性与2型糖尿病合并视网膜病变的关联性研究
Author: Xiaotong ZHUANG ¹ ; Meizi LU ; Xiuling YU ; Li XU
Author Information

1. 沈阳市第四人民医院眼科
Keywords: type 2 diabetes mellitus; retinopathy; GLIS3 gene
From: Journal of China Medical University 2017;46(10):909-912
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between the polymorphisms in GLIS3 and diabetic retinopathy in patients with type 2 diabetes in Northeast China.Methods Based on the case-control study,polymorphisms in GLIS3 were examined by PCR-RFLP in 120 cases of diabetic retinopathy in patients with type 2 diabetes (DR),120 cases of patients with type 2 diabetes without diabetic retinopathy (DNR),and 120 healthy individuals (NC).The odds ratio (OR) and 95％ confidence interval (C I) were calculated using unconditional logistic analysis.Results The resuhs demonstrated that GLIS3 rs7041847 AG,AG/GG genotype,or G allele was associated with an increased risk of DR and DNR (P ＜ 0.05).Moreover,GLIS3 rs7034200 CC,AC/CC genotype,or C allele was associated with an increased risk of DR and DNR (P ＜ 0.05).Conclusion In the patients in Northeast China,the polymorphisms in GLIS3 rs7041847 and rs7034200 were correlated with type 2 diabetes mellitus,while GLIS3 may not be associated with the susceptibility to diabetic retinopathy.