Efficacy and Safety of Metronidazole Combined with Hydrogen Peroxide for Uterine Cavity Lavage in the Treatment of Puerperal Infection:A Meta-analysis
10.6039/j.issn.1001-0408.2018.12.29
- VernacularTitle:甲硝唑联合过氧化氢冲洗宫腔治疗产褥感染疗效与安全性的Meta分析
- Author:
Bo ZHANG
1
;
Siyun YANG
;
Hua'an TENG
;
Yunbing SHU
;
Jianming DONG
Author Information
1. 宜宾市第三人民医院药剂科
- Keywords:
Metronidazole;
Hydrogenperoxide;
Puerperal infection;
Therapeutic efficacy;
Safety;
Meta-analysis
- From:
China Pharmacy
2018;29(12):1711-1714
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the efficacy and safety of metronidazole combined with hydrogen peroxide for uterine cavity lavage in the treatment of puerperal infection. METHODS:Retrieved from PubMed,Cochrane library,Wanfang database,VIP,CBM and CNKI,Meta-analysis was performed by using Cochrane collaboration Rev Man 5.3 software after data extraction and quality evaluation with modified Jadad scale. RESULTS:A total of 16 RCTs were included,involving 1 280 patients. Meta-analysis showed that total response rate of observation group was significantly higher than that of control group [OR＝5.76,95%CI(3.21,10.35),P＜0.001],but febrile duration [MD＝－2.08,95%CI(－2.32,－1.84),P＜0.001],duration of clinical symptom [MD＝－2.71,95%CI(－2.89,－2.53),P＜0.001] and average hospital stay [MD＝－3.05,95%CI(－3.32,－2.79),P＜0.001] are significantly shorter than control group; the incidence of ADR [OR＝0.27,95%CI(0.08,0.89),P＝0.03] was significantly lower than control group,with statistical significance. CONCLUSIONS:Metronidazole combined with hydrogen peroxide for uterine cavity lavage show good therapeutic efficacy and safety in the treatment of puerperal infection.
