Clinical Observation of Rupi Sanjie Capsules in the Treatment of Mammary Gland Hyperplasia after Minimally Invasive Rotation and Surgical
10.6039/j.issn.1001-0408.2018.12.22
- VernacularTitle:微创旋切术后给予乳癖散结胶囊治疗乳腺增生的临床观察
- Author:
Qingfu LYU
1
;
Lin CHEN
;
Zhaoji GUO
;
Wei CAO
;
Min JIANG
Author Information
1. 苏州大学附属第一医院普外科
- Keywords:
Rupi sanjie capsules;
Tamoxifen citrate tablets;
Minimally invasive rotation and surgical;
Mammary gland hyperplasia;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2018;29(12):1682-1684
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of Rupi sanjie capsules in the treatment of mammary gland hyperplasia after minimally invasive rotation and surgical. METHODS:A total of 180 patients with mammary gland hyperplasia or mammary gland hyperplasia combined with mammary fibroma were selected retrospectively from general surgery department of the First Affiliated Hospital of Soochow University during May 2015 to May 2017. They were divided into control group(n＝90)and observation group (n＝90) according to medication methods. Both groups received minimally invasive rotation and surgical treatment. After operation,control group was given Tamoxifen citrate tablets 10 mg orally,twice a day. Observation group was given Rupi sanjie capsules 2.12 g orally,3 times a day. Two groups stopped taking medication during menstruation,and both groups were treated for 8 weeks. Clinical efficacies of 2 groups were observed,and the levels of VEGF,FGF and MVD,the occurrence of ADR were observed before and after treatment. RESULTS:The total response rate of observation group(95.56%) was significantly higher than that of control group(86.67%),with statistical significance(P＜0.05). Before treatment,there was no statistical significance in the levels of VEGF,FGF and MVD between 2 groups (P＞0.05). After treatment,the levels of VEGF,FGF and MVD in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistical significance(P＜0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:After minimally invasive rotation and surgical,Rupi sanjie capsules shows significant therapeutic efficacy for mammary gland hyperplasia,can reduce the levels of VEGF,FGF and MVD with good safety.
