Effects of Dexmedetomidine on Neuron Injury Indexes,Inflammatory Factors and Spinal Cord Function of Cervical Operation Patients
10.6039/j.issn.1001-0408.2018.10.23
- VernacularTitle:右美托咪定对颈椎手术患者神经元损伤指标、炎性因子及脊髓功能的影响
- Author:
Songjiang TANG
1
;
Linghao WANG
Author Information
1. 贵阳中医学院第一附属医院麻醉科
- Keywords:
Dexmedetomidine;
Cervical operation;
Neu-ron;
Spinal cord;
Injury;
Inflammatory factor
- From:
China Pharmacy
2018;29(10):1388-1391
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of dexmedetomidine on neuron injury indexes,inflammatory factors and spinal cord function of cervical operation patients. METHODS:Totally of 112 patients underwent cervical operation of general anesthesia in our hospital during May 2015 to Nov. 2017 were divided into control group and dexmedetomidine group according to random number table,with 56 cases in each group. Anesthesia of both groups was totally maintained by intravenous anesthesia. Dexmedetomidine group was given intravenous infusion of Dexmeimidine hydrochloride injection with loading dose of 0.8 μg/kg and injection time of more than 10 min before anesthesia maintenance,and then was continuously pumped to 30 min before operation at the rate of 0.4 μg/(kg·h). The levels of neuron injury indexes (GFAP,NSE,MMP-9) and inflammatory factors (TNF-α,IL-6,IL-10)of 2 groups were observed before anesthesia induction(T0),1 h after operation(T1),1 d after operation (T2),7 d after operation (T3). Japanese Orthopedics Academy (JOA) scores of cervical vertebra were observed in 2 groups before operation and 7 d after operation,and VAS scores were also observed in 2 groups 1 d and 7 d after operation. The occurrence of ADR was recorded. RESULTS:Each 3 patients of 2 groups withdrew from the study,and each 53 patients of 2 groups completed the study. There was no statistical significance in neuron injury indexes or serum levels of inflammatory factors between 2 groups at T0 (P>0.05). At T1-T3,above indexes of both groups were significantly higher than at T0;the levels of GFAP,NSE,MMP-9,TNF-α and IL-6 in dexmedetomidine group were significantly lower than control group,while the level of IL-10 was significantly higher than control group,with statistical significance (P<0.05). There was no statistical significance in JOA score or VAS score between 2 groups before operation or 1 d after operation (P>0.05). Seven days after operation,JOA scores of 2 groups were increased significantly,while VAS scores were decreased significantly,with statistical significance(P<0.05);but there was no statistical significance between 2 groups (P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Additional use of dexmedetomidine before anesthesia maintenance can improve the serum levels of inflammatory factors in cervical operation patients,and relieve neuron spinal cord and injury to certain extent,but would not influence the safety of drug use.
