Clinical Observation of NB-UVB Combined with Total Glucosides of White Paeony Capsules and Urea Cream in the Treatment of Psoriasis Vulgaris
10.6039/j.issn.1001-0408.2018.08.23
- VernacularTitle:窄谱中波紫外线联合白芍总苷胶囊和尿素乳膏治疗寻常型银屑病的临床观察
- Author:
Mingxing XIE
1
;
Feng'e QI
;
Qiuhua MA
;
Lihua XU
;
Zengqiang XIE
;
Ying WANG
;
Yun ZHOU
Author Information
1. 浙江省长兴县人民医院皮肤科/浙江大学附属二院长兴院区皮肤科
- Keywords:
NB-UVB;
Total glucosides of white paeony capsules;
Urea cream;
Psoriasis vulgaris;
Efficacy;
Safety
- From:
China Pharmacy
2018;29(8):1106-1108
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of NB-UVB combined with Total glucosides of white paeony(TGP)capsules and Urea cream in the treatment of psoriasis vulgaris. METHODS:A total of 75 patients with psoriasis vulgaris in dermatology department of our hospital during Jan. 2015-Dec. 2016 were divided into control group(37 cases)and observation group(38 cases)according to random number table. Control group was given TGP capsules 0.6 g orally,3 times a day,reducing to 0.3 g,3 times a day if diarrhea or stool increased significantly after taking the medicine+Urea cream,smearing on the skin,day and evening,for consecutive 12 weeks. Observation group was additionally given NB-UVB irradiation with initial dose of 0.36 J/cm2,2 min/time,every other day,adjusted according to skin reaction for consecutive 8 weeks,on the basis of control group. Clinical efficacies of 2 groups were observed,and PASI scores before and after treatment and the occurrence of ADR were observed. RESULTS:One patient of observation group withdrew from therapy after suffering from obvious edematous erythema with pain due to irradiation. All patients of control group completed treatment. Total response rate of observation group (86.49%)was significantly higher than that of control group(56.76%),with statistical significance(P<0.05). Before treatment, there was no statistical significance in PASI scores between 2 groups(P>0.05). After treatment,PASI scores of 2 groups were significantly lower than before treatment,and observation group was significantly lower than control group,with statistical significance(P<0.05). There was no statistical significance in total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:NB-UVB combined with TGP capsules and Urea cream show good therapeutic efficacy and safety for psoriasis vulgaris,and can significantly decrease PASI score of patients.
