Present Analysis of Off-indication Drug Use of Drugs for High Altitude Pulmonary Edema

VernacularTitle:高原肺水肿治疗药物的超适应证用药现状分析
Author: Kexin LIU ¹ ; Xuewen HUANG ; Fuchun XU ; Ajiaerbu ; Jule WANG
Author Information

1. 四川大学华西医院临床药学部
Keywords: High altitude pulmonary edema; Treatment; Drugs; Off-indication use
From: China Pharmacy 2018;29(7):995-998
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To analyze the situation of off-indication drug use of drugs for high altitude pulmonary edema (HAPE),and to provide reference for promoting rational drug use in medical institutions of plateau area and establishing relevant management process. METHODS:By taking"HAPE""treatment""Altitude illness""Treatment"as keywords,retrieving from CNKI,PubMed,Embase database during build up to Sept. 2017,drugs for HAPE were screened and extracted after reading the literatures. Drug package inserts of listed preparations were compared,summarized and analyzed. RESULTS:Drugs for HAPE in literatures were screened,and 16 kinds of drugs were summarized finally as nifedipine,sildenafil,tadalafil,aminophylline,etc. Indication of HAPE was not found in drug package inserts of those listed preparations. CONCLUSIONS:At present,there is a universal phenomenon of off-indication drug use of drugs for HAPE,and it is imminent to regulate the management of off-label drug use in the hospital. It is suggested to improve the off-label drug use management flow of drugs for HAPE so as to promote rational drug use.