Study on Protective Effects of Polygonum hydropiper Extract on Acute Gastric Mucosal Injury in Rats
10.6039/j.issn.1001-0408.2018.07.22
- VernacularTitle:辣蓼提取物对大鼠急性胃黏膜损伤的保护作用研究
- Author:
Shouzhong REN
1
;
Wenqin SU
;
Hongrui ZHU
;
Ning WANG
;
Haiyan NIU
;
Yamei ZHAO
;
Zhijian MA
Author Information
1. 海南医学院药学院
- Keywords:
Polygonum hydropiper extract;
Acute gastric mucosal lesion;
Nuclear factor E2 related factor 2;
SOD;
Rats
- From:
China Pharmacy
2018;29(7):955-958
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protective effects of Polygonum hydropiper extract on acute gastric mucosal lesion (AGML)in rats. METHODS:48 rats were randomly divided into normal group(normal saline),model group(normal saline), positive group(ranitidine hydrochloride,0.05 g/kg),P. hydropiper extract low-dose,medium-dose and high-dose groups(2.7, 8.1,24.3 g/kg by crude drug),i.g. for consecutive 7 d,once a day. Except for normal group,other groups were given absolute ethyl alcohol to induce AGMI model after 1 h of last administration. 1.5 h after modeling,gastric mucosal lesion index of rats was calculated;the pathological changes of gastric tissue in rats were observed;nuclear factor E2 related factor 2(Nrf2)content and SOD activity in gastric tissue of rats were determined by ELISA. RESULTS:Compared with normal group,the gastric mucosa of model group was damaged obviously,there was blood capillary rupture in submucosa,gastric mucosal lesion index was increased significantly(P<0.01);Nrf2 content and SOD activity were significantly decreased in gastric tissue of rats(P<0.05 or P<0.01). Compared with model group,gastric mucosal lesion of rats was relieved to different extent;in positive group,P. hydropiper extract medium-dose and high-dose groups,gastric mucosal lesion index was decreased significantly(P<0.05),and Nrf2 content and SOD activity were increased significantly(P<0.05 or P<0.01). CONCLUSIONS:P. hydropiper extract has good protective effect on absolute ethyl alcohol-induce AGMI,the mechanism of which may be associated with raising Nrf2 content and enhancing SOD activity in gastric mucosal tissue.
