Optimization of Phencynonate Hydrochloride Transdermal Patch Formulation by Box-Behnken Design-response Surface Methodology
10.6039/j.issn.1001-0408.2018.07.08
- VernacularTitle:Box-Behnken设计-响应面法优化盐酸苯环壬酯透皮贴剂的处方
- Author:
Shiqin LIAO
1
;
Hui LIU
;
Jing ZHAO
;
Yanchen WANG
;
Zhenjun GUO
Author Information
1. 南方医科大学药学院
- Keywords:
Phencynonate hydrochloride;
Transdermal patch;
Accumulative transdermal volume;
Box-Behnken design-response surface methodology;
Formulation optimization
- From:
China Pharmacy
2018;29(7):897-901
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formulation of Phencynonate hydrochloride transdermal patch. METHODS:Phencynonate hydrochloride transdermal patch was prepared by solvent evaporation method. Using 48 h accumulative transdermal volume as index,single factor test and Box-Behnken design-response surface methodology were used to optimize drug dosage,the amount of transdermal enhancers azone and pressure-sensitive adhesive,and evaluate the appearance,adhesion of the formulation prepared by the best prescription. RESULTS:The optimized formulation was as follows as 263 mg drug dosage,165 mg azone, 1.94 g pressure-sensitive adhesive and 1.6 g methanol. 48 h accumulative transdermal volume of prepared patch was(119.48 ± 2.95)μ g/cm2(n=5),related error of which to predicted value was 2.48%. The prepared patch showed smooth surface and incision,good adhesiveness. CONCLUSIONS:Phencynonate hydrochloride transdermal patch is prepared successfully,its accumulative transdermal volume is in agreement with predicted standard.
