Meta-analysis of Therapeutic Efficacy of TCM External Treatment for Alopecia Areata and Investigation on the Regularity of Prescription Selection and Medicine Use
10.6039/j.issn.1001-0408.2018.06.25
- VernacularTitle:中药制剂外用治疗斑秃疗效的Meta分析及选方用药规律探讨
- Author:
Ming LEI
1
;
Bin YAO
;
Xiaoqian YU
;
Fang WANG
;
Weining LI
Author Information
1. 银川市中医医院
- Keywords:
TCM external treatment;
Alopecia areata;
Meta-analysis;
Regularity of medicine use
- From:
China Pharmacy
2018;29(6):828-832
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the therapeutic efficacy and safety of TCM external treatment for alopecia areata,and to investigate the regularity of prescription selection and medicine use. METHODS:Retrieved from PubMed,EMBase, Cochrane Library,CBM and CNKI,RCTs about TCM external treatment(trial group)vs. routine regimen(control group)in the treatment of alopecia areata were included. The qualities of included studies were evaluated with modified Jadad scale after literature screening and data extraction. Meta-analysis was conducted by using Rev Man 5.3 statistical software. Frequency statistics and ingredient analysis were conduced among included prescriptions. RESULTS:A total of 21 RCTs were included,involving 2 510 patients. Meta-analysis showed that total response rate of trial group was significantly higher than that of control group,with statistical significance [OR=4.14,95%CI(3.04,5.65),P<0.001]. There was no statistical difference in the incidence of ADR between 2 groups [OR=1.66,95%CI(3.04,5.65),P=0.48]. A total of 20 prescriptions among included 21 RCTs were included after the repeated prescriptions were deleted. Above prescriptions were analyzed statistically;there were 53 ingredients in 20 prescriptions,and the sum of use frequency for those ingredients was 138.The ingredients with high use frequency were Carthamus tinctorius,Platycladus orientalis,Salvia miltiorrhiza;main types of medicines were restoring vital energy,relieving exterior disorder,invigorating blood circulation and eliminating stasis,etc. CONCLUSIONS:TCM external treatment shows good therapeutic efficacy and safety. Medicines are mainly used for restoring vital energy,invigorating blood circulation and eliminating stasis.
