Analysis of Drug Resistance of 3 Non-fermentative Gram-negative Bacilli in Our Hospital during 2004-2016
10.6039/j.issn.1001-0408.2018.06.16
- VernacularTitle:我院2004-2016年3种非发酵革兰氏阴性杆菌耐药性分析
- Author:
Xiangpeng LI
1
;
Xian QIN
;
Fanbo JING
;
Yu LIANG
;
Jun ZHAO
;
Bing HAN
;
Lina WEI
;
Hongyan JI
;
Zhongguo SUI
Author Information
1. 青岛大学附属医院药学部
- Keywords:
Non-fermentative Gram-negative bacilli;
Pseudomonas aeruginosa;
Acinetobacter baumanii;
Stenotrophomonas maltophilia;
Antibiotics;
Drug resistance
- From:
China Pharmacy
2018;29(6):790-794
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for rational selection of antibiotics against non-fermentative Gram-negative bacilli in clinic. METHODS:Etiological data of clinical isolated Pseudomonas aeruginosa(PA),Acinetobacter baumanii(AB) and Stenotrophomonas maltophilia(SM)were collected from the Affiliated Hospital of Qingdao University(called"our hospital"for short)during Jan. 2004-Dec. 2016. Drug resistance of them to commonly used antibiotics was analyzed retrospectively. RESULTS:Totally 15 587 strains of PA,7 446 strains of AB and 2 950 strains of SM were detected. Resistance rates of PA to commonly used antibiotics fluctuated but were in a decreasing tendency. Except for imipenem,resistance rates of PA to commonly used antibiotics decreased significantly,and resistance rates of PA to amikacin and gentamicin decreased to 4.60% and 7.48%, respectively. Resistance rates of AB to most commonly used antibiotics were more than 40%,but it was sensitive to tigecycline (drug resistance of 0-4.03%). Resistance rates of SM to cefoperazone sodium and sulbactam sodium increased from 3.03% in 2004 to 39.01% in 2016,but it was sensitive to sulfamethoxazole,minocycline and levofloxacin. CONCLUSIONS:Non-fermentative Gram- negative bacilli detected in our hospital are mainly PA. Resistance rate of PA to most of the antibiotics is declining;drug resistance of AB is severe;resistance rates of SM to cefoperazone sodium and sulbactam sodium show increasing tendency.Above 3 non-fermentative Gram-negative bacilli are sensitive to amikacin,tegocycline and minocycline. Clinical selection should be based on the results of drug sensitivity test.
