Efficacy and Safety of Compound Kushen Colon-release Capsule versus Related Chemical Drugs in the Treatment of Colitis: A Meta-analysis
10.6039/j.issn.1001-0408.2018.05.30
- VernacularTitle:复方苦参结肠溶胶囊对比相关化学药治疗溃疡性结肠炎疗效和安全性的Meta分析
- Author:
Huibiao LI
1
;
Muyuan CHEN
;
Xinlin CHEN
;
Zhenwen QIU
;
Detang LI
;
Hongmei TANG
Author Information
1. 广州中医药大学第一附属医院药学部
- Keywords:
Compound kushen colon-release capsule;
Ulcertive colitis;
Meta-analysis;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2018;29(5):695-699
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To systematically evaluate therapeutic efficacy and safety of Compound kushen colon-release capsule versus related chemical drugs in treatment of ulcerative colitis (UC).METHODS: Retrieved from PubMed, Embase, Cochrane library, China Journal Full-text Database (CJFD), VIP, CBM and Wanfang database, RCTs about therapeutic efficacy (response rate, TCM syndrome, therapeutic efficacy of mucosal lesion) and safety (the incidence of ADR) of Compound kushen enteric-release capsule versus related chemical drugs in the treatment of UC were collected. Meta-analysis was conducted by using Rev Man 5. 3 statistical software after data extraction and quality evaluation with Cochrane 5. 1. 0. RESULTS: A total of 9 RCTs were included, involving 649 patients. The results of Meta-analysis showed that response rate [OR=2. 16, 95％CI(1. 28, 3. 63), P=0. 004] and therapeutic efficacy of mucosal lesion [OR=2. 42, 95％ CI(1. 07, 5. 47), P=0. 03] of Compound kushen colon-release capsule were significantly higher than that of chemical drugs in the treatment of UC, with statistical significance. There was no statistical significance in therapeutic efficacy of TCM syndrome [OR=1. 70, 95％CI(0. 87, 3. 32), P=0. 12] or the incidence of ADR between 2 groups. CONCLUSIONS: Therapeutic efficacy of Compound kushen colon-release capsule is better than that of related chemical drugs in the treatment of UC with similar safety.
