Effects of Ultrafine Grinding Technology on the Dissolution of Triterpenoids from Ganoderma lucidum
10.6039/j.issn.1001-0408.2018.05.06
- VernacularTitle:超微粉碎技术对灵芝中三萜类成分溶出的影响
- Author:
Fujun ZHANG
1
;
Jingtian QU
;
Qiang WANG
Author Information
1. 天津中医药大学第一附属医院药学部
- Keywords:
Ganoderma lucidum;
Ultrafine grinding technology;
Triterpenoids;
HPLC
- From:
China Pharmacy
2018;29(5):599-602
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the effects of ultrafine grinding technology on the dissolution of triterpenoids from Ganoderma lucidum.METHODS: UV spectrophotometry was used to determine total extration rates of triterpenoids from G. lucidum. HPLC method was used to determine the contents of 9 kinds of triterpenoids (ganoderic acid A, ganoderic acid B, ganoderic acid C, ganoderic acid C1, ganoderic acid C2, ganoderic acid D, ganoderic acid E, ganoderic acid G, ganoderic acid H) from G. lucidum. The total extration rates and the contents of 9 kinds of triterpenoids were compared between 30, 50, 80 mesh common G. lucidum powder and 300 mesh G. lucidum ultramicro powder. RESULTS: The total extraction rates of triterpenoids from 30, 50, 80, 300 mesh G. lucidum powder were (0. 74 ± 0. 08)％,(0. 75 ± 0. 06)％,(0. 78 ± 0. 06)％,(1. 09 ± 0. 10)％ (RSD< 2％, n=3), respectively. With the increase of the mesh number of G. lucidum powder, the contents of triterpenoids were increased gradually, and were the highest in 300 mesh, which was significant higher than common G. lucidum powder (P<0. 05). CONCLUSIONS: After ultrafine grinding, the dissolution of triterpenoids from G. lucidum is increased.
