Effects of Yupingfeng Granules on Immune Function and Related Indexes of Children with Allergic Rhinitis Complicated with Bronchial Asthma
10.6039/j.issn.1001-0408.2018.04.24
- VernacularTitle:玉屏风颗粒对变应性鼻炎合并支气管哮喘患儿免疫功能及相关指标的影响
- Author:
Shangjie BAI
1
;
Sha LIANG
;
Xiaojun LU
Author Information
1. 延边大学附属医院耳鼻咽喉头颈外科
- Keywords:
Yupingfeng granules;
Salmeterol xinafoate and fluticasone propionate;
Mometasone;
Allergic rhinitis;
Bronchial asthma;
Immune function;
Safety
- From:
China Pharmacy
2018;29(4):530-533
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effects of Yupingfeng granules on immune function and related indexes of children with allergic rhinitis (AR) complicated with bronchial asthma (BA). METHODS: Clinical information of 101 children with AR complicated with BA during Feb. 2014-Sept. 2017 were analyzed retrospectively, and they were divided into control group (47 cases) and observation group (54 cases) according to treatment plan. Control group was given Salmeterol xinafoate and fluticasone propionate powder for inhalation through mouth, one inhalation, twice a day+Mometasone furoate nasal spray 50 μg each nostril. Observation group was additionally given Yupingfeng granules 5 g orally, 3 times a day, for consecutive 2 weeks, drug withdrawal at 2 weeks interval, recycled 3 times. Both groups received treatment for consecutive 3 months. Clinical symptom and sign scores, the levels of T-lymphocyte subgroup (CD4+, CD8+, CD4+/CD8+), IL-4, IFN-γ and IgE before and after treatment, the occurrence of ADR were observed in 2 groups. RESULTS: Before treatment, there was no statistical significance in clinical symptom and sign scores, levels of T-lymphocyte subgroup, serum levels of IL-4, IFN-γ or IgE between 2 groups (P＞0. 05). After treatment, clinical symptom and sign scores, CD4+, CD4+/CD8+, serum levels of IL-4 and IgE in 2 groups were all significantly lower than before treatment; observation group was significantly lower than control group. CD8+ and serum levels of IFN-y in 2 groups after treatment were significantly higher than before treatment; observation group was significantly higher than control group, with statistical significance (P＜0. 05). There was no statistical significance in the incidence of ADR between 2 groups (P＞0. 05). CONCLUSIONS: Yupingfeng granules can effectively improve immune function of children with AR complicated with BA, and relieve clinical symptom without increasing the occurrence of ADR.
