Optimization of Water Extraction Technology of Feng-Moutan Cortex by Orthogonal Test-Multiple-index Normalization Method
10.6039/j.issn.1001-0408.2018.03.17
- VernacularTitle:正交试验-多指标归一化法优化凤丹皮水提工艺
- Author:
Pei WANG
1
;
Hongsu ZHAO
;
Deling WU
;
Fengqing XU
;
Wei ZHANG
;
Quanjiang LONG
;
Chengwu FANG
Author Information
1. 安徽中医药大学药学院
- Keywords:
Feng-Moutan Cortex;
Multiple-index;
Normalization method;
Orthogonal test;
Extraction technology;
Optimization
- From:
China Pharmacy
2018;29(3):361-364
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To optimize water extraction technology of Feng-Moutan Cortex. METHODS: L9 (34) orthogonal design was used to optimize soaking time, solid-liquid ratio, extraction time and extraction times in water extraction technology of Feng-Moutan Cortex using comprehensive scores for the peak area percentage and extract yield of 8 ingredients in Feng-Moutan Cortex as gallic acid, paeoniflorin, catechin, paeoniflorin, benzoic acid, benzoyloxypaeoniflorin, benzoylpaeoniflorin and paeonol after normalization as indexes. Verification test was conducted. RESULTS: The optimal water extraction technology was that 20-fold water, soaking for 1 h, extracting twice, 2 h each time. Results of verification test showed that comprehensive scores of 3 times of tests were 65. 98, 68. 85 and 69. 25, respectively. RSDs of each index were lower than 5％ (n=3). CONCLUSIONS: Established comprehensive scoring method can reflect the relative contents of effective components in Feng-Moutan Cortex comprehen- sively, so that optimized extraction technology is reasonable and feasible.
