Preparation and Quality Evaluation of Formononetin Inclusion Compound Liposome
10.6039/j.issn.1001-0408.2018.03.04
- VernacularTitle:芒柄花素包合物脂质体的制备及质量评价
- Author:
Cancheng LIAO
1
;
Bohong GUO
;
Danqiao XU
;
Xiujun WU
;
Jun YI
;
Zexian HUANG
Author Information
1. 广东药科大学药学院
- Keywords:
Formononetin;
Inclusion compound;
Liposome;
Quality evaluation
- From:
China Pharmacy
2018;29(3):303-306
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare Formononetin (FMN) inclusion compound liposome and evaluate its quality. METHODS: FMN inclusion compound liposome was prepared by film dispersion method. The morphology, particle size, Zeta potential, encapsulation efficiency and in vitro release properties were studied. RESULTS: The particle size, Zeta potential and encapsulation efficiency of prepared FMN inclusion compound liposome were (255. 34 ± 12. 87) nm, (25. 32 ± 3. 51) mV, (81. 63 ± 0. 79)％, respectively (n=3). The 24 h accumulative release rate of prepared FMN inclusion compound liposome was 56. 12％. CONCLUSIONS: FMN inclusion compound liposome with good sustained-release effect is prepared successfully and in line with related quality standard.
