Risk of the Gastric Cancer Associated with the Interleukin 1beta Gene Polymorphism and Helicobacter pylori.
10.5230/jkgca.2004.4.3.149
- Author:
Sang Hyub PARK
1
;
Kyo Young SONG
;
Jin Jo KIM
;
Hyung Min JIN
;
Wook KIM
;
Cho Hyun PARK
;
Seung Man PARK
;
Keun Woo LIM
;
Woo Bae PARK
;
Seung Nam KIM
;
Hae Myung JEON
Author Information
1. Department of Surgery, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. hmjeon@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Gastric cancer;
Helicobacter pylori;
Interleukin 1beta;
Polymorphism
- MeSH:
DNA;
Gastric Acid;
Gastritis;
Gastritis, Atrophic;
Genotype;
Helicobacter pylori*;
Helicobacter*;
Humans;
Incidence;
Interleukin-1beta*;
Interleukins*;
Polymorphism, Genetic;
Risk Factors;
Stomach Neoplasms*
- From:Journal of the Korean Gastric Cancer Association
2004;4(3):149-155
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: According to the recent studies, it is shown that the polymorphism of Interleukin 1beta gene is associated with the incidence of gastric cancer caused by the Helicobacter pylori infection. Interleukin 1beta is a cytokine markedly inhibiting gastric acid secretion. Interleukin 1beta production associated with Helicobacter pylori gastric infection may exacerbate mucosal damage including chronic gastritis and atrophic gastritis, may induce eventual neoplasia. Among these Interleukin 1beta gene polymorphisms, polymorphisms at -31 portion and -511 portion may associated with these processes, eventually increase the risk of gastric cancer. We investigated the risk of gastric cancer according to the Helicobacter pylori infection and genetic polymorphism of Interleukin 1beta in gastric cancer patients. MATERIALS AND METHODS: 176 individuals with gastric cancer and 40 healthy controls were analyzed. Each group was divided into two groups whether they infected with Helicobacter pylori or not. DNA was extracted from the peripheral blood in all groups. The PCR-RFLP method was used for investigating the distribution of genotype of C/C, C/T, T/T at -31 portion and -511 portion. RESULTS: T/T genotype at -511 portion was 19.3% in gastric cancer cases and 10% in controls, which was statistically significant. (P=0.0432) The risk of gastric cancer was increased 4.86 (1.26~18.77) in group which had T/T genotype. In gastric cancer cases, C/C genotype at 31 portion was 27.6% in group with Helicobacter pylori infection and 12.8% in group without infection, which was statistically significant. (P=0.0047) The risk of gastric cancer was increased 4.82 (1.81~12.81) in group which had C/C genotype. CONCLUSION: T genotype at -511 portion among the Interleukin 1beta genetic polymorphisms may be the risk factor of gastric cancer. And, with Helicobacter pylori infection, C genotype at -31 portion may be the risk factor of gastric cancer.
