Literature Analysis of Study on Optimal Sampling Points of Clinical Pharmacokinetics Based on Maximum a Posteriori Bayesian Method
10.6039/j.issn.1001-0408.2018.02.16
- VernacularTitle:基于最大后验贝叶斯法的临床药动学采样点优化研究的文献分析
- Author:
Zijian HE
1
;
Ying ZHAN
;
Hua SHAO
;
Feng YU
Author Information
1. 中国药科大学基础医学与临床药学学院
- Keywords:
Maximum a posteriori Bayesian;
Multiple linear regression;
Optimal sampling strategy;
Therapeutic drug monitoring;
Pharmacokinetics;
Population pharmacokinetics
- From:
China Pharmacy
2018;29(2):210-215
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for the study of optimal sampling points in clinical pharmacokinetics.METHODS:The literatures about optimal sampling points in clinical pharmacokinetics were searched from CNKI,Wanfang database,VIP,PubMed,Medline,ScienceDirect and other databases during Jan.2011-Jun.2016 using "Bayesian estimate(s)""Bayesian estimator(s) Bayesian analysis" "Limited" "Optimal" "Sparse" "Minimal sampling" as retrieval words.The systematic analysis and evaluation were conducted.RESULTS:A total of 1 Chinese literature and 13 English literatures were involved respectively.The drugs they focused on were mainly immunosuppressive agents,antiviral drugs,antibiotics,pediatric individualized medication,etc.Multiple linear regression (MLR) was still the most widely used method in China,while maximum a posteriori Bayesian (MAPB) method was more popular in foreign studies.MLR equation was simple and easy to use,but the sampling was very strict.MAPB method could be completed with less sampling points and sampling time;it was more suitable for clinical practice,but needed professional software.The precision and accuracy of the two methods were similar.The research methods of optimal sampling strategy were quite different but all included 4 steps as prior information ganining,reference value determination,sampling point optimization,prediction capability verification.CONCLUSIONS:MAPB method requires less sampling points and it results are relatively accurate and reliable.It is more suitable for clinical practice and optimal sampling study of clinical pharmacokinetics.
