Efficacy Comparison of Erlotinib between Late Non-small Cell Lung Cancer Patients with EGFR Exon 19 Mutation and Those with Exon 21 Mutation
10.6039/j.issn.1001-0408.2018.01.21
- VernacularTitle:厄洛替尼对EGFR外显子19与21突变晚期非小细胞肺癌患者的疗效比较
- Author:
Kegui WENG
1
;
Bing GUO
;
Yanhua HOU
;
Yong JIANG
;
Ying WANG
;
Yudong WANG
Author Information
1. 重庆市肿瘤研究所/重庆市肿瘤医院/重庆市癌症中心肿瘤放疗科
- Keywords:
Tyrosine kinase inhibitors;
Erlotinib;
Epidermal growth factor receptor;
Late non-small cell lung cancer;
Efficacy
- From:
China Pharmacy
2018;29(1):81-84
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the clinical efficacy of erlotinib between late non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) exon 19 mutation and those with exon 21 mutation.METHODS:Late NSCLC patients with EGFR mutation positive enrolled in our hospital during Oct.2013-Nov.2014 were selected.Patients with EGFR exon 19 Del mutant were regarded as group A,and patients with exon 21 L858R mutant were regarded as group B,45 cases in each group.All patients were orally administered with Edotinib hydrochloride tablets till progression.The disease control rate (DCR),median survival time (MST),median time to progress (mTTP),one-year survival rate and incidence of adverse reactions in 2 groups were compared.RESULTS:The DCR (93.02％) and one-year survival rate (81.40％) in group A were obviously higher than that of group B (72.09％,60.47％) (P＜0.05),MST [(15.47 ± 2.87) month] and mTTP [(182.00 ± 8.24) d] were obviously longer than that of group B [(12.55 ± 2.92) month,(162.00 ± 7.22) d] (P＜0.01).There was no statistical significance in the incidence of adverse reactions in 2 groups (P＞0.05),and there were no severe adverse reactions.CONCLUSIONS:For patients with late NSCLC,erlotinib shows superior efficacy in patients with EGFR exon 19 mutation to patients with EGFR exon 21 mutation.
