Clinical Observation of Vinpocetine Combined with Xueshuantong in the Treatment of Cerebral Infarction
10.6039/j.issn.1001-0408.2017.36.11
- VernacularTitle:长春西汀联合血栓通治疗急性脑梗死的临床观察
- Author:
Sujie WANG
1
;
Pei LI
;
Jiang LIU
;
Lili CHEN
;
Li YUAN
Author Information
1. 唐山市工人医院神经内科
- Keywords:
Vinpocetine;
Xueshuantong;
Cerebral infarction;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2017;28(36):5079-5082
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of vinpocetine combined with xueshuantong in the treatment of cerebral infarction.METHODS:56 patients with acute cerebral infarction were randomly divided into control group (28 cases) and observation group (28 cases).On the basis of routine treatment,control group was given Vinpocetine for injection 20 mg,once a day.Observation group was additionally given Xueshuantong for injection (lyophilized) 150 mg,intravenously,once a day,on the basis of control group.Both groups received treatment for 2 weeks.Clinical efficacies of 2 groups were observed.The levels ofNIHSS score、VEGF,vWF,sVCAM-1,sICAM-1,CRP and IL-8,the occurrence of ADR were observed before and after treatment.RESULTS:Total response rate of observation group (96.43％) was significantly higher than that of control group (78.57％),with statistical significance (P＜0.05).After treatment,the serum levels of VEGF in 2 groups were significantly higher than before treatment,and the observation group was significantly higher than the control group.The serum levels of NIHSS score、vWF,sVCAM-1,sICAM-1,CRP and IL-8 in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistical significance (P＜0.05).There was no statistical significance in the incidence of ADR between 2 groups (P＞0.05).CONCLUSIONS:Based on routine treatmem,vinpocetine combined with xueshuantong show good therapeutic efficacy and safety for cerebral infarction.
